What is the metabolome

Metabolome

Scientists understand a metabolome to be the entirety of those metabolic products that a tissue type produces at a certain point in time and under specific conditions, and thereby itself Metabolite profiles to be able to research the effects of new active ingredients. Such profiles can also be created for brain cells, for example, to identify neurodegenerative processes such as Disease Parkinson to be able to investigate. As is well known, Parkinson's is characterized by specific changes in the brain cells, with changes in the shape of the cells as well as their function and the underlying metabolic processes. So far it has only been possible to single out a few of the numerous aspects in order to describe and better understand the mechanisms of the disease, but with the examination of the metabolome of the brain cells, significantly more of those substances can be analyzed, the nerve cells in the higher, middle and lower lying ones Brain regions produce. This compares healthy brains and brains in which neurodegenerative processes have taken place - so far, usually only in animal experiments. The method of gas chromatography in combination with mass spectrometry, which is particularly suitable for the analysis of complex tissue samples, is used to investigate the metabolite profiles. With the help of metabolite profiles, it is hoped, especially when testing potential active substances, to be able to make more precise statements about their effects on the diseased nerve cells than is possible with microscopic methods or the analysis of individual biomolecules.

The term metabolome was analogous to the terms Genome, Transcriptome and Proteome shaped and derived from the concept of metabolism from.


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